Cyclodextrin and Meglumine-Based Microemulsions as a Poorly Water-Soluble Drug Delivery System
نویسندگان
چکیده
منابع مشابه
Hydrogel-Based Drug Delivery Systems for Poorly Water-Soluble Drugs.
Hydrogels are three-dimensional materials that can withstand a great amount of water incorporation while maintaining integrity. This allows hydrogels to be very unique biomedical materials, especially for drug delivery. Much effort has been made to incorporate hydrophilic molecules in hydrogels in the field of drug delivery, while loading of hydrophobic drugs has not been vastly studied. Howeve...
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The majority of drugs have a low dissolution rate, which is a limiting step for their absorption. In this manuscript, solid dispersions (SD), solid self-microemulsifying drug delivery systems (S-SMEDDS) and solid self-nanoemulsifying drug delivery systems (S-SNEDDS) were evaluated as potential formulation strategies to increase the dissolution rate of carbamazepine. Influence of increased disso...
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The drug candidates coming from combinatorial chemistry research and/or the drugs selected from biologically based high-throughput screening are quite often very lipophilic, as these drug candidates exert their pharmacological action at or in biological membranes or membrane-associated proteins. This challenges drug delivery institutions in industry or academia to develop carrier systems for th...
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Masatoshi Nakatsuji, Haruka Inoue, Masaki Kohno, Mayu Saito, Syogo Tsuge, Shota Shimizu, Osamu Ishibashi Osaka Prefecture University, Graduate School of Life and Environmental Sciences 1-1 Gakuen-cho, Nakaku, Sakai, Osaka 599-8531, Japan [email protected]; [email protected]; [email protected]; [email protected]; [email protected]; sv...
متن کاملEffect of Cyclodextrin Types and Co-Solvent on Solubility of a Poorly Water Soluble Drug
The aim of the study was to investigate the solubility of piroxicam (Prx) depending on the inclusion complexation with various cyclodextrins (CDs) and on ethanol as a co-solvent. The phase-solubility method was applied to determine drug solubility in binary and ternary systems. The results showed that in systems consisting of the drug dissolved in ethanol-water mixtures, the drug solubility inc...
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ژورنال
عنوان ژورنال: Journal of Pharmaceutical Sciences
سال: 2016
ISSN: 0022-3549
DOI: 10.1016/j.xphs.2015.11.045